Search on: CARBOXYPEPTIDASE B2 
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Descriptor English:   Carboxypeptidase B2 
Descriptor Spanish:   Carboxipeptidasa B2 
Descriptor Portuguese:   Carboxipeptidase B2 
Synonyms English:   Carboxypeptidase R
Plasma Procarboxypeptidase B
Procarboxypeptidase U
Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)
Plasma Carboxypeptidase B2
Thrombin Activatable Fibrinolysis Inhibitor
Arginine Carboxypeptidase
Thrombin-Activatable Fibrinolysis Inhibitor
Carboxypeptidase B2, Plasma
Carboxypeptidase U  
Tree Number:   D08.811.277.656.350.245.125
D08.811.277.656.350.555.225
D08.811.277.656.675.555.225
D08.811.277.656.837.092
Definition English:   A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS. 
History Note English:   2015 (2002); use CARBOXYPEPTIDASE U (NM) 1994-2001 and LYSINE CARBOXYPEPTIDASE 1997-2001 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   36082 
Unique Identifier:   D025901 

Occurrence in VHL:
 

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